Why kinetic folding matters in RNA design
RNA design is incomplete when equilibrium structure is treated as the sole criterion. Folding kinetics becomes essential whenever pathway, timing, or metastable intermediates contribute to function.
Showing only posts tagged RNA folding kinetics. Show all posts.
Bayesian approximation of RNA folding times
This workshop paper introduces the core KinPFN idea: approximating RNA first-passage-time distributions with a prior-data fitted network trained on synthetic folding-time priors.
KinPFN for RNA folding kinetics
KinPFN uses prior-data fitted networks to approximate first-passage-time distributions for RNA folding kinetics orders of magnitude faster than direct simulation.
Co-transcriptional riboswitch modeling with ViennaRNA
A landscape-based method for modeling how cotranscriptional folding and ligand binding interact in kinetically controlled riboswitches, illustrated with the 2'dG riboswitch from Mesoplasma florum.
In silico design of ligand-triggered RNA switches
A computational workflow for designing ligand-triggered RNA switches, with emphasis on sequence design, folding kinetics, and candidate prioritization.
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