Conserved RNA regulatory switches in living cells
Transcriptome-scale ensemble mapping combined with covariation analysis reveals conserved RNA thermometers in bacteria and regulatory 5' UTR switches in human cells.
Showing only posts tagged RNA structure prediction. Show all posts.
Predicting RNA structures from sequence and probing data
This review explains how classical thermodynamic RNA folding models can be improved with chemical probing data, and why that combination remains one of the most reliable routes to biologically useful structure prediction.
SHAPE directed RNA folding with the ViennaRNA Package
This paper shows how SHAPE-guided RNA folding is implemented in the ViennaRNA Package, comparing three widely used strategies for turning nucleotide reactivities into soft constraints that improve thermodynamic structure prediction.