Expert Support for RNA Structure, Design, and Analysis

When This Kind of Support Is Useful

• You have an RNA construct or design concept and want an independent expert view before committing to synthesis or experiments.
• Your team needs practical training in ViennaRNA, RNA structure prediction, or structure-aware RNA design.
• You have RNA data but need mechanistic interpretation to move forward with confidence.
• You are preparing a grant, a go/no-go decision, or an internal review and need focused, credible scientific input.

RNA Design Review

An RNA design review is an independent written assessment of your construct, design strategy, or computational approach. You send the relevant materials such as sequences, design notes, slides, or a manuscript section. I then prepare a structured technical review that looks at the design logic, the main assumptions, likely weak points, and sensible next steps. A follow-up call can be added if discussion would help.

This format is often useful when a team wants a credible external view before committing time, synthesis, or experimental effort.

What You Receive

Depending on the material you provide and the scope we agree on, a design review typically includes:

• a short written memo or annotated slide deck
• a clear statement of the main technical risks, uncertainties, and assumptions
• practical recommendations for the next computational or experimental step
• an optional follow-up discussion to clarify tradeoffs and priorities

Who This Is Best Suited For

This kind of support is usually most useful for:

• research groups planning a new RNA construct or assay series
• biotech teams making a go or no-go decision on a candidate design
• projects where computational results need interpretation before further experiments are commissioned
• teams that want an external expert view without building a full in-house RNA informatics function

Example Review Question

A typical request sounds like this:

"We have three candidate switch designs that all satisfy the same equilibrium constraints, but they differ in local alternatives around the aptamer and expression platform. Which construct is least likely to fail once folding kinetics, accessibility, and the intended assay conditions are taken into account?"

Questions like that are usually less about producing one more structure plot and more about deciding which assumptions are solid enough to justify synthesis.

Computational RNA Workshops

I also offer hands-on training in RNA structure prediction, ViennaRNA, and structure-aware RNA design for research teams, academic groups, and doctoral programmes. Workshops are available in short, half-day, and full-day formats, either remotely or onsite, and are scoped in advance to fit the background of the group.

See the workshops page for full details on available formats and how sessions are organised.

Advisory Support

For teams that need ongoing input rather than a single review or workshop, I offer selected advisory arrangements. These usually combine regular calls with asynchronous review of materials and short written notes. The focus stays close to the questions the team is actively working through, whether that is design logic, computational interpretation, or planning the next experimental step.

Get in Touch

If you are unsure which format fits your situation, write a few lines about what you are working on and I will suggest a sensible starting point.