RNA Structure, Function, and Design

Much of RNA biology only comes into focus once structure, folding, and molecular context are taken seriously.

I am Michael T. Wolfinger, and my work focuses on the computational side of that problem: structure prediction, folding kinetics, structure-aware RNA design, RNA-protein recognition, and structured viral RNAs. I am particularly interested in RNA systems where function depends on architecture, folding history, or interaction geometry in ways that are not obvious from sequence alone.

I am a Principal Investigator at the University of Vienna and affiliated with the Theoretical Biochemistry Group (TBI), a long-standing centre for RNA bioinformatics and home of the ViennaRNA Package.

Across my research, the common thread is a structure-aware view of RNA function, regulation, and design.