Michael Thomas Wolfinger

As a theoretical biochemist with a deep passion for computational RNA biology, I am fascinated by the potential of synthetic biology to revolutionize our world. My work bridges the gap between theoretical understanding and the design of novel biological systems. This includes leveraging computational approaches to explore new frontiers, particularly within the exciting field of virus bioinformatics.
Michael T. Wolfinger

The study of RNA viruses holds particular significance for synthetic biology. My research on RNA viruses provides a deep understanding of their complex interplay between structure and function, which is crucial for designing novel biological systems. This includes:

  • Predicting the intricate structures of RNA molecules in 2D and 3D
  • Designing molecular devices like riboswitches for synthetic biology applications
  • Uncovering RNA's hidden complexities through RNA structure probing
  • Advancing RNA structure prediction with artificial intelligence
  • Investigating the fascinating world of RNA-protein interactions
  • Revealing co-transcriptional RNA folding dynamics
  • Exploring multifaceted RNA folding dynamics and energy landscapes

These research areas collectively fuel my commitment to advancing our understanding of RNA and its broader significance in the realm of synthetic biology, biotechnology, and healthcare.

I currently lead research as a Principal Investigator at the University of Vienna. Previously, I held a visiting professor position at the University of Freiburg Bioinformatics Group. I maintain affiliations with the Research Group Bioinformatics and Computational Biology (BCB) and the Theoretical Biochemistry Group (TBI) at the Department of Theoretical Chemistry, University of Vienna. These academic groups are renowned for their contributions to the development of the ViennaRNA Package, a widely used resource in the field of RNA bioinformatics.

Beyond my academic endeavors, I have established RNA Forecast, a venture with a mission to emphasize the significance of RNA structure within the pharmaceutical and biotechnology sectors. Together, we strive to integrate the One Health approach with the power of virus bioinformatics to tackle the complex challenges posed by RNA viruses, safeguarding the health of all living organisms on our planet.