General and miRNA-mediated mRNA degradation occurs on ribosome complexes in Drosophila cells

mRNA degradation in Drosophila cells

mRNA degradation and translation are two processes crucial for posttranscriptional gene regulation. While the strong interconnection of mRNA degradation and translation has been noted for many years, it has led to the hypothesis that mRNAs could be degraded on the ribosome.

We have recently published a study that strongly supports the hypothesis that the ribosome is a very general site not only for general 5' to 3' mRNA degradation in Drosophila but also for the miRNA-mediated mRNA degradation pathway:

Posted by Michael T. Wolfinger on . updated