In this study we show that mRNA degradation occurs on ribosome complexes in Drosophila cells
mRNA degradation and translation are two processes crucial for
posttranscriptional gene regulation. While the strong interconnection of
mRNA degradation and translation has been noted for many years, it has led
to the hypothesis that mRNAs could be degraded on the ribosome.
In the present study we provide evidence that the ribosome is a universal site not only for general 5' to 3' mRNA degradation in Drosophila but also for the miRNA-mediated mRNA degradation pathway.