Hfq, Crc, and antibiotic resistance in P. aeruginosa
Here we study carbon catabolite repression (CCR) and its impact on antibiotic susceptibility in Pseudomonas aeruginosa
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Co-transcriptional folding as a key factor in riboswitch function
In the realm of gene regulation, understanding the precise mechanisms by which RNA molecules fold and function during transcription is crucial. This study delves into this intricate process, focusing on the type I-A 2′-deoxyguanosine (2'dG)-sensing riboswitch from Mesoplasma florum. By employing NMR spectroscopy and computational modeling, we have uncovered critical insights into how co-transcriptional folding influences ligand binding and conformational switching in these regulatory RNAs.
Bacterial transcription start site annotation from dRNA-seq data
A RESTful web service and standalone application for automated de-novo annotation of bacterial transcription start sites from dRNA-seq data