Hfq, Crc, and antibiotic resistance in P. aeruginosa
Here we study carbon catabolite repression (CCR) and its impact on antibiotic susceptibility in Pseudomonas aeruginosa
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Co-transcriptional riboswitch modleing with ViennaRNA
Riboswitches are RNA molecules that regulate gene expression by sensing metabolites, presenting an interesting target for synthetic biology applications. We present a computational approach based on ViennaRNA tools to dissect and model RNA-ligand interaction dynamics under kinetic control, enabling simulation of riboswitch folding
Co-transcriptional folding as a key factor in riboswitch function
We investigate the influence of co-transcriptional folding on ligand binding and conformational switching in a type I-A 2'-deoxyguanosine (2'dG)-sensing riboswitch from Mesoplasma florum
TSSAR: Bacterial transcription start site annotation from dRNA-seq data
A RESTful web service and standalone application for automated de-novo annotation of bacterial transcription start sites from dRNA-seq data