Beyond Pango: The future of virus lineage classification
Keeping pace with ever-changing viruses is a challenge. This study unveils an automated system for classifying viral lineages based on genetics, offering a faster and more objective approach
Keeping pace with ever-changing viruses is a challenge. This study unveils an automated system for classifying viral lineages based on genetics, offering a faster and more objective approach
On One Health Day, we recognize the intricate links between human, animal, and environmental health, underscored by the emergence of novel viruses like SARS-CoV-2. This post, crafted for a lay audience, delves into the critical contributions of virus bioinformatics in understanding and combating infectious diseases. It emphasizes the importance of predicting RNA structures for understanding RNA viruses and discusses the role of genomic epidemiology in tracking viral spread and evolution
We identified a conserved G-quadruplex structure in the Zika virus's 3' terminal region, which interacts with human DEAD-box helicases, DDX3X and DDX17. These findings suggest new potential therapeutic targets for the development of treatments against the virus
Unraveling the intricate RNA-RNA interactions in Japanese encephalitis virus (JEV) opens new possibilities for understanding viral replication and designing antiviral therapeutics, as our recent study reveals the importance of a conserved cyclization sequence in driving these interactions
In this mini-review we discuss the concept of RNA structure conservation in viruses, using exoribonuclease-resistant RNAs from flaviviruses as prominent examples