Mar 23 2023 Strukturierte RNAs in Viren (in German)

In this mini-review we discuss the concept of RNA structure conservation in viruses, using exoribonuclease-resistant RNAs from flaviviruses as prominent examples

Nov 18 2022 The link between mRNA vaccine design and barbeque optimization

The rational design of vaccine mRNAs and barbeque share common traits: Both require extensive optimization and benefit from experience

Mar 25 2019 Comparative look at flavivirus UTRs: Similarities and surprises

This study highlights the crucial role of untranslated regions (UTRs) in flaviviruses and the discovery of exoribonuclease resistant RNAs (xrRNAs). These findings showcase the importance of virus bioinformatic studies in advancing our understanding of infectious diseases and their relevance to broader health goals

Jul 01 2018 Co-transcriptional riboswitch modleing with ViennaRNA

Riboswitches are RNA molecules that regulate gene expression by sensing metabolites, presenting an interesting target for synthetic biology applications. We present a computational approach based on ViennaRNA tools to dissect and model RNA-ligand interaction dynamics under kinetic control, enabling simulation of riboswitch folding

Jul 01 2018 In silico design of ligand triggered RNA switches

In the world of synthetic biology, the design of RNA switches holds immense promise for various applications, ranging from diagnostics to therapeutics. This paper presents a comprehensive workflow for designing RNA switches that can dynamically alter their structural conformations in response to specific ligands