synthetic biology
Posts tagged “synthetic biology”.
Sequence editability of the theophylline RNA aptamer
Molecular dynamics of five theophylline aptamer variants whose binding site is left unchanged: which edits in the surrounding helices keep ligand recognition intact, and which weaken it from the outside.
Rational design of mechanically active RNAs
This Nucleic Acids Research paper shows that synthetic xrRNAs can be designed from topological rules and validated experimentally as mechanically active RNAs.
A first look at rational design of mechanically active RNAs
A preprint-stage note on the design logic behind synthetic xrRNAs and mechanically active RNAs.
Exploring RNA Biology with Deep Learning Algorithms
An RNA Biology article collection on deep learning methods in transcriptomics, RNA structure prediction, and molecular design.
Strukturierte RNAs in Viren (in German)
In this mini-review we discuss the concept of RNA structure conservation in viruses, using exoribonuclease-resistant RNAs from flaviviruses as prominent examples