Strukturierte RNAs in Viren (in German)
In this mini-review we discuss the concept of RNA structure conservation in viruses, using exoribonuclease-resistant RNAs from flaviviruses as prominent examples
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RNA secondary structure conservation and molecular epidemiology of TBEV
In this paper, we study the molecular epidemiology and RNA structureome diversity of tick-borne encephalitis virus (TBEV). Moreover, we propose a unified picture of pervasive non-coding RNA structure conservation across all known TBEV subtypes
Functional RNA structures in the 3'UTR of Mosquito-Borne Flaviviruses
The 3'UTR of Mosquito-Borne Flaviviruses (MBFVs) contain evolutionarily conserved functional elements, such as exoribonuclease-resistant RNAs (xrRNAs), dumbbell elements or terminal stem-loops. In this contribution we describe, annotate, and compare these elements within different serological groups of MBFVs
Mpulungu Virus: A Glimpse into Africa's Novel Tick-Borne Flavivirus
The discovery of Mpulungu virus (MPFV), a novel tick-borne flavivirus in Zambia, expands our understanding of the geographical distribution and genetic diversity of flaviviruses across Africa. This study delves into the genetic details of MPFV, suggesting its potential to infect vertebrate hosts and underscoring the importance of a One Health approach in addressing emerging infectious diseases
Unraveling Flavivirus UTRs: xrRNAs and the Path to One Health
This study highlights the crucial role of untranslated regions (UTRs) in flaviviruses and the discovery of exoribonuclease resistant RNAs (xrRNAs). These findings showcase the importance of virus bioinformatic studies in advancing our understanding of infectious diseases and their relevance to broader health goals like the One Health approach.