Functional RNA structures are often preserved long after primary sequence similarity becomes weak or misleading. In those cases, comparative analysis has to look for conserved architecture, compensatory change, and shared structural logic rather than sequence identity alone.
A mechanics-aware RNA design workflow identifies topological design rules for xrRNAs and produces fully synthetic exoribonuclease-resistant RNAs with wild-type-like XRN1 resistance.
A Viruses Special Issue on functional RNAs in virology, covering structured RNAs, RNA-protein interactions, and RNA-based regulation in viral infection.
A comparative analysis of vsiRNA profiles across insect-specific flaviviruses reveals unusually strong 3' UTR-biased siRNA production that is independent of sfRNA formation.
Xinyang flavivirus defines a basal, likely tick-only orthoflavivirus clade and expands the comparative picture of vertebrate-independent flavivirus evolution.