Rational design of mechanically active RNAs
This Nucleic Acids Research paper shows that synthetic xrRNAs can be designed from topological rules and validated experimentally as mechanically active RNAs.
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When sequence conservation is not enough to find functional RNA structure
Functional RNA structures are often preserved long after primary sequence similarity becomes weak or misleading. In those cases, comparative analysis has to look for conserved architecture, compensatory change, and shared structural logic rather than sequence identity alone.
A first look at rational design of mechanically active RNAs
A preprint-stage note on the design logic behind synthetic xrRNAs and mechanically active RNAs.
Functional RNAs in Virology Special Issue
A Viruses Special Issue on functional RNAs in virology, covering structured RNAs, RNA-protein interactions, and RNA-based regulation in viral infection.
3' UTR-biased siRNA production in an insect-specific flavivirus
A comparative analysis of vsiRNA profiles across insect-specific flaviviruses reveals unusually strong 3' UTR-biased siRNA production that is independent of sfRNA formation.
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