Jun 09 2023 RNA-protein complex refinement using AI modeling and docking

This study presents an efficient technique for refining protein-RNA complexes using AI-based modeling and flexible docking. The method, utilizing parallel cascade selection molecular dynamics (PaCS-MD), accelerates conformational sampling of flexible RNA regions and produces high-quality complex models. Experimental validation demonstrates its superiority over template-based modeling, suggesting its potential for constructing complexes with non-canonical RNA-protein interactions

Mar 31 2023 RNA–RNA interaction analysis of Japanese encephalitis virus

Unraveling the intricate RNA-RNA interactions in Japanese encephalitis virus (JEV) opens new possibilities for understanding viral replication and designing antiviral therapeutics, as our recent study reveals the importance of a conserved cyclization sequence in driving these interactions

Jul 26 2022 Musashi-1 RNA-binding protein's role in RNA recognition

In this contribution we study the association complexes of the RNA-binding protein Musashi-1 with different RNA motifs, using molecular dynamics simulations

Feb 03 2022 Japanese encephalitis virus genome cyclization is kinetically driven

This study uses biophysical and bioinformatics methods to assess the long-range RNA-RNA interaction between terminal regions of Japanese encephalitis virus

Jan 20 2022 Biophysical characterisation of human lincRNA-p21 Alu inverted repeats

In this study we determine the tertiary structure of human LincRNA-p21 Alu Inverted Repeats with biophysical and computational approaches