Rational design of mechanically active RNAs
This Nucleic Acids Research paper shows that synthetic xrRNAs can be designed from topological rules and validated experimentally as mechanically active RNAs.
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A first look at rational design of mechanically active RNAs
A preprint-stage note on the design logic behind synthetic xrRNAs and mechanically active RNAs.
Why kinetic folding matters in RNA design
RNA design is incomplete when equilibrium structure is treated as the sole criterion. Folding kinetics becomes essential whenever pathway, timing, or metastable intermediates contribute to function.
Strukturierte RNAs in Viren (in German)
In this mini-review we discuss the concept of RNA structure conservation in viruses, using exoribonuclease-resistant RNAs from flaviviruses as prominent examples
The link between mRNA vaccine design and barbeque optimization
A short podcast appearance on optimization, data sharing, and what mRNA design can teach us about iterative engineering problems.
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