Showing only posts tagged RNA-Protein interaction. Show all posts.

RNA-Protein Complex Refinement using AI Modeling and Docking

This study presents an efficient technique for refining protein-RNA complexes using AI-based modeling and flexible docking. The method, utilizing parallel cascade selection molecular dynamics (PaCS-MD), accelerates conformational sampling of flexible RNA regions and produces high-quality complex models. Experimental validation demonstrates its superiority over template-based modeling, suggesting its potential for constructing complexes with non-canonical RNA-protein interactions.