The link between mRNA vaccine design and barbeque optimization
A short podcast appearance on optimization, data sharing, and what mRNA design can teach us about iterative engineering problems.
Showing only posts tagged synthetic biology. Show all posts.
Comparative genomics of flavivirus 3' UTR RNA structures
A comparative genomics analysis of flavivirus 3' UTRs that identifies conserved exoribonuclease-resistant RNAs and lineage-specific architectural variation across tick-borne, insect-specific, and no-known-vector flaviviruses.
Co-transcriptional riboswitch modeling with ViennaRNA
A landscape-based method for modeling how cotranscriptional folding and ligand binding interact in kinetically controlled riboswitches, illustrated with the 2'dG riboswitch from Mesoplasma florum.
In silico design of ligand-triggered RNA switches
A computational workflow for designing ligand-triggered RNA switches, with emphasis on sequence design, folding kinetics, and candidate prioritization.
Co-transcriptional folding and metastable states in riboswitch function
This paper uses NMR spectroscopy to resolve transcription intermediates of the 2'dG riboswitch at single-nucleotide resolution, showing how transcript length and metastable states govern ligand-controlled switching.
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