Insect-specific flaviviruses evade antiviral RNAi
In this paper, we explore the role of RNA interference (RNAi) in mosquito immunity by comparing viral small interfering RNA (siRNA) profiles across different insect-specific flaviviruses
In this paper, we explore the role of RNA interference (RNAi) in mosquito immunity by comparing viral small interfering RNA (siRNA) profiles across different insect-specific flaviviruses
In this paper, we report the discovery of Xinyang flavivirus (XiFV), a novel virus isolated from Haemaphysalis flava ticks in China. Through phylogenetic analysis, we found that XiFV is closely related to other tick-only flaviviruses, such as Mpulungu flavivirus (MPFV) from Zambia and Ngoye virus (NGOV) from Senegal. This positions XiFV in a unique clade of orthoflaviviruses, a group that seems to infect only ticks, without any known vertebrate host
We identified a conserved G-quadruplex structure in the Zika virus's 3' terminal region, which interacts with human DEAD-box helicases, DDX3X and DDX17. These findings suggest new potential therapeutic targets for the development of treatments against the virus
Unraveling the intricate RNA-RNA interactions in Japanese encephalitis virus (JEV) opens new possibilities for understanding viral replication and designing antiviral therapeutics, as our recent study reveals the importance of a conserved cyclization sequence in driving these interactions
This study uses biophysical and bioinformatics methods to assess the long-range RNA-RNA interaction between terminal regions of Japanese encephalitis virus