Hfq, Crc, and antibiotic resistance in P. aeruginosa

Here we study carbon catabolite repression (CCR) and its impact on antibiotic susceptibility in Pseudomonas aeruginosa

This study on Pseudomonas aeruginosa underscores the interplay between microbial metabolism and antibiotic resistance, which has implications for human, animal, and environmental health. The observed link between carbon catabolite repression (CCR) and antibiotic susceptibility suggests that the microbial response to environmental nutrients can impact the efficacy of antibiotics. This insight is crucial as antibiotic-resistant strains can pose threats to both human healthcare and animal husbandry. Understanding such regulatory mechanisms can guide the development of targeted interventions, aligning with the One Health approach that seeks to optimize health outcomes across different domains of the ecosystem.


Rewiring of Gene Expression in Pseudomonas aeruginosa During Diauxic Growth Reveals an Indirect Regulation of the MexGHI-OpmD Efflux Pump by Hfq
Marlena Rozner, Ella Nukarinen, Michael T. Wolfinger, Fabian Amman, Wolfram Weckwerth, Udo Blaesi, Elisabeth Sonnleitner
Front. Microbiol. (2022) 13:919539 | doi:10.3389/fmicb.2022.919539 | PDF