Jun 23 2022 Hfq, Crc, and antibiotic resistance in P. aeruginosa

This study on Pseudomonas aeruginosa underscores the interplay between microbial metabolism and antibiotic resistance, which has implications for human, animal, and environmental health. The observed link between carbon catabolite repression (CCR) and antibiotic susceptibility suggests that the microbial response to environmental nutrients can impact the efficacy of antibiotics. This insight is crucial as antibiotic-resistant strains can pose threats to both human healthcare and animal husbandry. Understanding such regulatory mechanisms can guide the development of targeted interventions, aligning with the One Health approach that seeks to optimize health outcomes across different domains of the ecosystem.