Lineage-specific RNA structures in Chikungunya virus

Changing a single nucleotide of an RNA may completely disrupt its structure

Here we studied this effect in Chikungunya virus, which causes millions of human infections every year. Using molecular epidemiology data, we found single nucleotide variants that change the stability and fold of locally stable RNA structures throughout the viral genome.

Figures and Data


Dynamic Molecular Epidemiology Reveals Lineage-Associated Single-Nucleotide Variants That Alter RNA Structure in Chikungunya Virus
Thomas Spicher, Markus Delitz, Adriano de Bernardi Schneider, Michael T. Wolfinger
Genes 12 (2):239 (2021) | doi:10.3390/genes12020239 | PDF

Posted by Michael T. Wolfinger on . updated