RNA secondary structure conservation and molecular epidemiology of TBEV

In this paper, we study the molecular epidemiology and RNA structureome diversity of tick-borne encephalitis virus (TBEV). Moreover, we propose a unified picture of pervasive non-coding RNA structure conservation across all known TBEV subtypes

We show that the TBEV 3′ architectural diversity is realized by a combination of a restricted pool of eight structural and one non-structural element, suggesting that the observed 3′UTR variability is driven by structural, rather than sequence conservation.

Figures and Data


Evolutionary traits of Tick-borne encephalitis virus: Pervasive non-coding RNA structure conservation and molecular epidemiology
Lena S. Kutschera, Michael T. Wolfinger
Virus Evol. (8):1 veac051 (2022) | doi: 10.1093/ve/veac051 | PDF | Supplementary data

Posted by Michael T. Wolfinger on . updated