The pivotal role of virus bioinformatics in global health

On One Health Day, we recognize the intricate links between human, animal, and environmental health, underscored by the emergence of novel viruses like SARS-CoV-2. This post, crafted for a lay audience, delves into the critical contributions of virus bioinformatics in understanding and combating infectious diseases. It emphasizes the importance of predicting RNA structures for understanding RNA viruses and discusses the role of genomic epidemiology in tracking viral spread and evolution

Zika virus: Unlocking cures with G-quadruplex structures

We identified a conserved G-quadruplex structure in the Zika virus's 3' terminal region, which interacts with human DEAD-box helicases, DDX3X and DDX17. These findings suggest new potential therapeutic targets for the development of treatments against the virus

RNA-protein complex refinement using AI modeling and docking

This study presents an efficient technique for refining protein-RNA complexes using artifilial intelligence (AI) based modeling and flexible docking. The method, utilizing parallel cascade selection molecular dynamics (PaCS-MD), accelerates conformational sampling of flexible RNA regions and produces high-quality complex models. Experimental validation demonstrates its superiority over template-based modeling, suggesting its potential for constructing complexes with non-canonical RNA-protein interactions

RNA–RNA interaction analysis of Japanese encephalitis virus

Unraveling the intricate RNA-RNA interactions in Japanese encephalitis virus (JEV) opens new possibilities for understanding viral replication and designing antiviral therapeutics, as our recent study reveals the importance of a conserved cyclization sequence in driving these interactions

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