Jun 09 2023 RNA-protein complex refinement using AI modeling and docking

This study presents an efficient technique for refining protein-RNA complexes using artifilial intelligence (AI) based modeling and flexible docking. The method, utilizing parallel cascade selection molecular dynamics (PaCS-MD), accelerates conformational sampling of flexible RNA regions and produces high-quality complex models. Experimental validation demonstrates its superiority over template-based modeling, suggesting its potential for constructing complexes with non-canonical RNA-protein interactions

Mar 31 2023 RNA–RNA interaction analysis of Japanese encephalitis virus

Unraveling the intricate RNA-RNA interactions in Japanese encephalitis virus (JEV) opens new possibilities for understanding viral replication and designing antiviral therapeutics, as our recent study reveals the importance of a conserved cyclization sequence in driving these interactions

Mar 23 2023 Strukturierte RNAs in Viren (in German)

In this mini-review we discuss the concept of RNA structure conservation in viruses, using exoribonuclease-resistant RNAs from flaviviruses as prominent examples

Nov 18 2022 The link between mRNA vaccine design and barbeque optimization

The rational design of vaccine mRNAs and barbeque share common traits: Both require extensive optimization and benefit from experience

Jul 26 2022 Musashi-1 RNA-binding protein's role in RNA recognition

In this contribution we study the association complexes of the RNA-binding protein Musashi-1 with different RNA motifs, using molecular dynamics simulations