In this paper, we study the molecular epidemiology and RNA structureome diversity of tick-borne encephalitis virus (TBEV). Moreover, we propose a unified picture of pervasive non-coding RNA structure conservation across all known TBEV subtypes
Machine learning of RNA structure is more challenging than you might think. Using synthetic data from ViennaRNA's RNAfold to study the capabilities and shortcomings of neural networks for RNA secondary structure prediction in a controlled setting, we argue that shortcomings in the artificial setting will translate to real data
The 3'UTR of Mosquito-Borne Flaviviruses (MBFVs) contain evolutionarily conserved functional elements, such as exoribonuclease-resistant RNAs (xrRNAs), dumbbell elements or terminal stem-loops. In this contribution we describe, annotate, and compare these elements within different serological groups of MBFVs
Here we characterize a pseudoknot in the 5'UTR Internal Ribosome Entry Site (IRES) of Bovine Viral Diarrhea Virus (BVDV) using SHAPE-guided RNA structure probing and computational modelling of secondary and tertiary structures
Changing a single nucleotide of an RNA may completely disrupt its structure